PUBLICATIONS

Gabra M, Pastrello C, Machado N, Chow J.T.C, Kotlyar M, Tokar T, Jurisica I, Salmena L. Essential gene networks in acute myeloid leukemia identified using a microRNA-knockout CRISPR library screen.  bioRxiv  661140; doi: https://doi.org/10.1101/661140, 2019.

 

Zaman T,Sun P, Narod SA, Salmena L,Kotsopoulos J. Plasma RANKL levels are not associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers. Oncotarget  10(25):2475-2483 2018

Moran O, Zaman T, Eisen A, Demsky R Blackmore K, Knight JA, Elser C, Ginsburg O, Zbuk K1, Yaffe, Narod SA, Salmena L, Kotsopoulos J.  Serum osteoprotegerin levels and mammographic density among high-risk women. Cancer Causes & Control  29:507 2018

Dzneladze I, Woolley JF, Rossell C, Han Y, Rashid A, Jain M, Reimand J, Minden MD, Salmena L. SubID, a non-median dichotomization tool for heterogeneous populations, reveals the pan-cancer significance of INPP4B and its regulation by EVI1 in AML. PLoS ONE 13(2): e0191510. 2018

 

Gabra MM Salmena L. microRNAs and Acute Myeloid Leukemia Chemoresistance: A Mechanistic Overview. Frontiers in Oncology. 7:255, 2017

 

Odén L, Akbari M, Zaman T, Singer CF, Sun P, Narod SA, Salmena L, Kotsopoulos J. Plasma osteoprotegerin and breast cancer risk in BRCA1 and BRCA2 mutation carriers. Oncotarget. 7(52):86687-86694, 2016

 

Chehade R, Pettapiece-Phillips R, Salmena L, Kotlyar M, Jurisica I, Narod SA, Akbari MR, Kotsopoulos J. Reduced BRCA1 transcript levels in freshly isolated blood leukocytes from BRCA1 mutation carriers is mutation specific. Breast Cancer Research. 18(1):87, 2016.

 

Woolley, JF, Salmena L. Measurement of PTEN by Flow Cytometry. Methods in Molecular Biology. 1388:39-51, 2016.

 

Salmena L. PTEN: History of a Tumor Suppressor. Methods in Molecular Biology. 1388:3-11, 2016.

 

Pettapiece-Phillips R, Kotlyar M, Chehade R, Salmena L, Narod SA, Akbari MR, Jurisica I, Kotsopoulos J. Uninterrupted sedentary behavior downregulates BRCA1 gene expression. Cancer Prev Res (Phila). 9(1):83-8, 2015.

 

Bralha FN, Liyanage SU, Hurren R, Wang, X, Son MH, Fung TA, Chingcuanco FB, Tung AYV, Andreazza AC, Psarianos P, Schimmer AD, Salmena L and Laposa RR. Targeting mitochondrial RNA polymerase in acute myeloid leukemia. Oncotarget. Nov 10;6(35):37216-28 2015.

 

Salmena L, Shaw P, Fans I, McLaughlin, Rosen B, Risch H, Mitchell C, Sun P, Narod SA, Kotsopoulos J. Prognostic value of INPP4B protein immunohistochemistry in ovarian cancer. Eur J Gynaecol Oncol. 2015;36(3):260-7.

 

Woolley JF, Dzneladze I, Salmena L. Phosphoinositide signaling in cancer: INPP4B Akt(s) out. 

Trends Mol Med. 2015 Sep;21(9):530-2. doi: 10.1016/j.molmed.2015.06.006. Epub 2015 Jul 3.

 

Li Chew C, Lunardi A, Gulluni F, Ruan DT, Chen M, Salmena L, Nishino M, Papa A, Ng C, Fung J, Clohessy JG, Sasaki J, Sasaki T, Bronson RT, Hirsch E, Pandolfi PP. In Vivo Role of INPP4B in Tumor and Metastasis Suppression through Regulation of PI3K-AKT Signaling at Endosomes. Cancer Discov. 2015 Jul;5(7):740-51. doi: 10.1158/2159-8290.CD-14-1347. Epub 2015 Apr 16.

 

Dzneladze I, He R, Woolley JF, Hi Son M, Sharobim MH, Greenberg SA, Gabra M, Langlois C, Rashid A, Hakem A, Ibrahimova N, Arruda A, Minden MD, Salmena L.  INPP4B overexpression is associated with poor clinical outcome and therapy resistance in acute myeloid leukemia. Leukemia 2015 Mar 4. doi: 10.1038/leu.2015.51. [Epub ahead of print]

 

Salmena L. Pseudogene redux with new biological significance. Methods Mol Biol. 1167:3-13.  2014

 

Song MS, Salmena L, Pandolfi PP.  The functions and regulation of the PTEN tumor suppressor. Nature Reviews Molecular Cell Biology 13(5):283-96, 2012

 

Narod SA, Salmena L.  BRCA1 and BRCA2 mutations and breast cancer. Discovery Medicine 12:445-53, 2011

 

Tay Y, Kats L, Salmena L, Weiss D, Tan SM, Ala U, Karreth F, Poliseno L, Provero P, Di Cunto F, Lieberman F, Rigoutsos I, Pandolfi PP. Coding-Independent Regulation of the Tumor Suppressor PTEN by Competing Endogenous mRNAs. Cell, 147: 344–357, 2011.

 

Salmena L, Poliseno L, Tay Y, Kats L, Pandolfi PP. The ceRNA hypothesis: the Rosetta stone of a hidden microRNA-dependent language. Cell, 146:353-358, 2011.

 

Poliseno L*, Salmena L*, Zhang, J, Carver, B, Haveman, W.J, Pandolfi PP.  A coding-independent function of gene and pseudogene mRNAs regulates tumour biology. Nature, 465:1033-8, 2010.

*shared first authorship.


Poliseno L, Salmena L, Riccardi, L, Fornari, A, Song, M.S, Hobbs, R.M, Sportoletti, P, Varmeh, S, Egia, A, Fedele, G,Rameh, L, Loda, M, Pandolfi PP.  Identification of the miR-106b~25 microRNA Cluster as a Proto-Oncogenic PTEN-Targeting Intron that Cooperates with its Host Gene MCM7 in Transformation.  Science Signaling, 3(117):ra29, 2010


Gewinner C, Wang ZC, Richardson A, Teruya-Feldstein J, Etemadmoghadam D, Bowtell D, Barretina J, Lin WM, Rameh L, Salmena L, Pandolfi PP, Cantley LC. Evidence that Inositol Polyphosphate 4-Phosphatase Type II Is a Tumor Suppressor that Inhibits PI3K Signaling.  Cancer Cell, 16:115-25, 2009

Song MS, Salmena L, Carracedo A, Egia A, Lo-Coco F, Teruya-Feldstein J, Pandolfi PP. The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network.  Nature, 455:813-7, 2008.

 

Salmena L, Carracedo A, Pandolfi PP. Tenets of PTEN tumor suppression.  Cell, 133:403-14, 2008.

 

Salmena L, Pandolfi PP. Changing venues for tumour suppression: balancing destruction and localization by monoubiquitylation. Nature Reviews Cancer, 7:409-13, 2007.

 

Salmena L, Hakem R. Caspase-8 Deficiency in T-Cells Leads to a Lethal Lymphoinfiltrative Immune Disorder. The Journal of Experimental Medicine, 202:727-32, 2005.

 

Salmena L, Lemmers B, Hakem A, Matysiak-Zablocki E, Murakami K, Au PY, Berry DM, Tamblyn L, Shehabeldin A, Migon E, Wakeham A, Bouchard D, Yeh WC, McGlade JC, Ohashi PS, Hakem R. Essential role for caspase-8 in T-cell homeostasis and T-cell-mediated immunity.  Genes & Development, 17:883-95, 2003.